Sulfuric Acid → 1-Methylethyl 2-hydroxy-5-(1-oxooctadecyl)benzoate

HRID 2309147ノート

反応式

HRID 2309147 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11](=[O:29])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH:35](O)([CH3:37])[CH3:36]>>[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11](=[O:29])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:7][C:3]=1[C:4]([O:6][CH:35]([CH3:37])[CH3:36])=[O:5]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 51009112-Hydroxy-5-(1-oxooctadecyl)benzoic acid

生成物 1

HCID 133934571-Methylethyl 2-hydroxy-5-(1-oxooctadecyl)benzoate

実験手順

A solution of the title product of Example 4 (6.2 mmole) and sulfuric acid (0.5 ml) in 120 ml of isopropyl alcohol (100 ml) was heated at 45° C. for 12 days, refluxed for 36 hours, and concentrated on a rotary evaporator to an oil. The oil was dissolved in methylene chloride, washed with water, dried over sodium sulfate, filtered, and concentrated under vacuum to give the title compound, m.p. 72°-73° C.

後処理

  1. temperaturerefluxed for 36 hours
  2. concentrationconcentrated on a rotary evaporator to an oil
  3. dissolutionThe oil was dissolved in methylene chloride
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-cdd273367a164bb49b96553940804b75
出典データセット
uspto-grants-1987_09
特許番号
US04692552

反応ノート

読み込み中…