HCID 20186023、化合物 → HCID 20186009、化合物

HRID 2309192ノート

反応式

HRID 2309192 の反応式
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:30]=[CH:31][CH:32]=2)[O:11][CH2:12][CH2:13][CH2:14][C:15]2[NH:20][C:19](=[O:21])[C:18]([O:22]CC3C=CC=CC=3)=[CH:17][N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:30]=[CH:31][CH:32]=2)[O:11][CH2:12][CH2:13][CH2:14][C:15]2[NH:20][C:19](=[O:21])[C:18]([OH:22])=[CH:17][N:16]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

3

反応物 1

HCID 20186023HCID 20186023、化合物

生成物 1

HCID 20186009HCID 20186009、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2-[3-[3-(Piperidinomethyl)phenoxy]propyl]-5-benzyloxypyrimidin-4-one (0.68 g) was stirred under reduced pressure and taken to pH 8 with hours in lN hydrochloric acid (20 ml). The mixture was concentrated under reduced pressure and taken to pH 8 with aqueous sodium bicarbonate. This mixture was extracted with n-butanol (3×20 ml); these extracts were combined, washed with water (2'5 ml), dried (MgSO4) and evaporated under reduced pressure to give the title compound. This was dissolved in methanol containing ethanolic HCl, excess solvent was evaporated under reduced pressure and the residue crystallised from isopropanol-acetone to give 2-[3-[3-(piperidinomethyl)phenoxy]propyl]-5-hydroxypyrimidin -4-one dihydrochloride (0.24 g), m.p. 192°-4° C.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. extractionThis mixture was extracted with n-butanol (3×20 ml)
  3. washwashed with water (2'5 ml),
  4. dry with materialdried (MgSO4)
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-24b85461beab4b6a9fbd6be26f0676f3
出典データセット
uspto-grants-1987_09
特許番号
US04694008

反応ノート

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