Glyoxylic Acid → Trans 4-(2,5-dimethyl-3-furyl)-4-oxo-2-butenoic Acid
反応式
[C:1]([C:4]1[CH:8]=[C:7]([CH3:9])[O:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[C:11]([OH:15])(=[O:14])[CH:12]=O>O>[CH3:10][C:5]1[O:6][C:7]([CH3:9])=[CH:8][C:4]=1[C:1](=[O:3])/[CH:2]=[CH:12]/[C:11]([OH:15])=[O:14]参加物
4
実験手順
As in Example 1, one starts out with 9 g of 3-acetyl 2.5-dimethylfuran (J. Am. Chem. Soc., 70 739 (1948)), 6 g glyoxylic acid and 6 cm3 water. Following chromatography on silica (eluent: petroleum ether-ethyl acetate (2-8), recrystallization in ethyl acetate, 1.8 g of the expected product is obtained. MP=144°-147° C.
後処理
- custompetroleum ether-ethyl acetate (2-8), recrystallization in ethyl acetate
出典と根拠
- ORDレコード
- ord-7053e5b61ed6406cbd5d0791d2f73b7d
- 出典データセット
- uspto-grants-1987_09
- 特許番号
- US04694019
反応ノート
読み込み中…