反応式
[Zn:1].[CH3:2][CH2:3][C@@H:4]([C:23]([C@H:25]([C@@H:27]([OH:43])[C@@H:28]([CH2:30][CH2:31][C:32]1[CH:33]=[CH:34][C:35]([CH3:42])=[C:36]([OH:41])[C:37]=1[C:38]([OH:40])=[O:39])[CH3:29])[CH3:26])=[O:24])[C@H:5]1[O:9][C@@:8]([C@@H:12]2[O:17][C@@H:16]([CH3:18])[C@@:15]([OH:21])([CH2:19][CH3:20])[CH2:14][CH2:13]2)([CH2:10][CH3:11])[CH2:7][C@@H:6]1[CH3:22].[CH3:44][CH2:45][C@@H:46]([C@@H:48]1[NH:79][C:77](=[O:78])[C@@H:76]([CH2:80][CH2:81][CH2:82][NH2:83])[NH:75][C:73](=[O:74])[C@@H:72]([NH:84][C:85]([C@@H:87]([NH:92][C:93]([C@H:95]([NH:101][C:102]([C@@H:104]([NH:109][C:110]([C@H:112]2[N:116]=[C:115]([C@@H:117]([NH2:122])[C@H:118]([CH2:120][CH3:121])[CH3:119])[S:114][CH2:113]2)=[O:111])[CH2:105][CH:106]([CH3:108])[CH3:107])=[O:103])[CH2:96][CH2:97][C:98]([OH:100])=[O:99])=[O:94])[C@H:88]([CH2:90][CH3:91])[CH3:89])=[O:86])[CH2:71][CH2:70][CH2:69][CH2:68][NH:67][C:65](=[O:66])[C@H:64]([CH2:123][C:124]([NH2:126])=[O:125])[NH:63][C:61](=[O:62])[C@@H:60]([CH2:127][C:128]([OH:130])=[O:129])[NH:59][C:57](=[O:58])[C@H:56]([CH2:131][C:132]2[NH:136][CH:135]=[N:134][CH:133]=2)[NH:55][C:53](=[O:54])[C@@H:52]([CH2:137][C:138]2[CH:139]=[CH:140][CH:141]=[CH:142][CH:143]=2)[NH:51][C:49]1=[O:50])[CH3:47]>CO>[CH3:44][CH2:45][C@@H:46]([C@@H:48]1[NH:79][C:77](=[O:78])[C@@H:76]([CH2:80][CH2:81][CH2:82][NH2:83])[NH:75][C:73](=[O:74])[C@@H:72]([NH:84][C:85]([C@@H:87]([NH:92][C:93]([C@H:95]([NH:101][C:102]([C@@H:104]([NH:109][C:110]([C@H:112]2[N:116]=[C:115]([C@@H:117]([NH2:122])[C@H:118]([CH2:120][CH3:121])[CH3:119])[S:114][CH2:113]2)=[O:111])[CH2:105][CH:106]([CH3:107])[CH3:108])=[O:103])[CH2:96][CH2:97][C:98]([OH:100])=[O:99])=[O:94])[C@H:88]([CH2:90][CH3:91])[CH3:89])=[O:86])[CH2:71][CH2:70][CH2:69][CH2:68][NH:67][C:65](=[O:66])[C@H:64]([CH2:123][C:124]([NH2:126])=[O:125])[NH:63][C:61](=[O:62])[C@@H:60]([CH2:127][C:128]([OH:130])=[O:129])[NH:59][C:57](=[O:58])[C@H:56]([CH2:131][C:132]2[NH:136][CH:135]=[N:134][CH:133]=2)[NH:55][C:53](=[O:54])[C@@H:52]([CH2:137][C:138]2[CH:139]=[CH:140][CH:141]=[CH:142][CH:143]=2)[NH:51][C:49]1=[O:50])[CH3:47].[Zn:1].[CH3:2][CH2:3][C@@H:4]([C:23]([C@H:25]([C@@H:27]([OH:43])[C@@H:28]([CH2:30][CH2:31][C:32]1[CH:33]=[CH:34][C:35]([CH3:42])=[C:36]([OH:41])[C:37]=1[C:38]([OH:40])=[O:39])[CH3:29])[CH3:26])=[O:24])[C@H:5]1[O:9][C@@:8]([C@@H:12]2[O:17][C@@H:16]([CH3:18])[C@@:15]([OH:21])([CH2:19][CH3:20])[CH2:14][CH2:13]2)([CH2:10][CH3:11])[CH2:7][C@@H:6]1[CH3:22]参加物
実験手順
A solution of 2.5 g of zinc lasalocid in 50 ml of methanol was stirred and 3.0 g of regular bacitracin was added. The mixture was stirred to dissolve all solids. The resulting solution was set aside and held at ambient temperature for 24 hours. The precipitated complex was isolated, rinsed with methanol, and dried; wt. 2.3 g. Analytical sample was recrystallized from methylene chloride and methanol. The crude complex was dissolved at room temperature in a mixture of 90% methylene chloride and 10% methanol. Solution was filtered to remove traces of insoluble and the complex recovered from the filtrate by the slow addition of additional methanol. The complex was also recovered from the filtrate by the slow removal of the methylene chloride under reduced pressure at 30°-35° C.
後処理
- dissolutionto dissolve all solids
- customThe precipitated complex was isolated
- washrinsed with methanol
- customdried
- customAnalytical sample was recrystallized from methylene chloride and methanol
- dissolutionThe crude complex was dissolved at room temperature in a mixture of 90% methylene chloride and 10% methanol
- filtrationSolution was filtered
- customto remove traces of insoluble and the complex
- customrecovered from the filtrate by the slow addition of additional methanol
- customThe complex was also recovered from the filtrate by the slow removal of the methylene chloride under reduced pressure at 30°-35° C.
出典と根拠
- ORDレコード
- ord-35aaa235f1614b6989b5041b56da8bd3
- 出典データセット
- uspto-grants-1987_09
- 特許番号
- US04693992
関連ノート
読み込み中…