Hydrochloric Acid → 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid

HRID 2309235

反応式

HRID 2309235 の反応式
[NH2:1][CH:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1.Cl>CC(C)=O.O>[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH:1][CH:2]([CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][CH:5]=2)[C:13]([OH:15])=[O:14])=[O:28])=[CH:25][CH:24]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 1148Dl-TryptophanHCID 85014-Chlorobenzoyl chlorideHCID 11430Potassium Carbonate

生成物 1

HCID 27875262-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒2 回

実験手順

10 Grams of DL-tryptophane was dissolved in a mixture of 100 ml of acetone with 20 ml of water, then to this solution was added 6 g of potassium carbonate. Under an ice-cooled condition, 9 g of 4-chlorobenzoyl chloride was added dropwise to the above-mentioned mixture, and the reaction mixture was stirred at the same temperature for 2 hours. Then, acetone was removed by evaporation, to the residue thus obtained was added water, and mixture was acidified by adding concentrated hydrochloric acid, the crystals formed were collected by filtration, and washed with water. Recrystallized from ethanol to obtain 14 g of 2-(4-chlorobenzoylamino)-3-(indol-3-yl)propionic acid. White powdery substance.

後処理

  1. additionwas added dropwise to the above-mentioned mixture
  2. customThen, acetone was removed by evaporation, to the residue
  3. customthus obtained
  4. customthe crystals formed
  5. filtrationwere collected by filtration
  6. washwashed with water
  7. customRecrystallized from ethanol

出典と根拠

ORDレコード
ord-424afda66e394569ac6515d23402e828
出典データセット
uspto-grants-1987_09
特許番号
US04694017

関連ノート

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