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L-Tryptophan → 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Tryptophan | HCID 6305 | — |
| 反応物 | 4-Chlorobenzoyl chloride | HCID 8501 | — |
| 生成物 | 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid | HCID 2787526 | 79.2% |
反応手順
By using 10 g of L-tryptophane and 9 g of 4-chlorobenzoyl chloride, and a method similar to that described in reference example 6, recrystallized from methanol-water there was obtained 13.3 g of 2-(4-chlorobenzoylamino)-3-(indol-3-yl)propionic acid in the form of colorless needle-like crystals. Melting point: 100°-102° C. [α]D25 -49.3° (C=1, methanol)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04694017 |
| 出典データセット | uspto-grants-1987_09 |
| ORD ID | ord-6cb5cc7566c5475a81c2b4ea40e7bc08 |
| 出典メモ | uspto-grants-1987_09 |