HCID 13489807、化合物 → 2-(1,2-Oxazol-4-yl)aniline
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:11]=[N:12][O:13][CH:14]=1)([O-])=O>Cl>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:11]=[N:12][O:13][CH:14]=1参加物
3
反応条件
- 温度
- 10 °C
実験手順
To a suspension of 108 g of stannous chloride dihydrate in 270 ml of concentrated hydrochloric acid was added portionwise 30 g of 4-(2-nitrophenyl)isoxazole prepared in Example 10 at less than 30° C. The suspension was stirred at about 20°-35° C. for 10 hours, then cooled to 10° C. and filtered. The solid was added to ice-water (400 ml), 50% NaOH was added to make the suspension basic to a pH of about 10, and the resultant suspension filtered. The solid was washed 3×100 ml of water and suction dried to give 18 g of the title compound; m.p. 48°-51° C.
後処理
- filtrationfiltered
- additionThe solid was added to ice-water (400 ml), 50% NaOH
- additionwas added
- filtrationthe resultant suspension filtered
- washThe solid was washed 3×100 ml of water and suction
- customdried
出典と根拠
- ORDレコード
- ord-5c26ab56f90a447794ecc686048bd9d6
- 出典データセット
- uspto-grants-1987_09
- 特許番号
- US04695311
反応ノート
読み込み中…