Potassium Carbonate → HCID 70353795、化合物
反応式
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]([OH:26])=[C:9]([CH2:12][CH2:13][CH2:14]OS(C3C=CC(C)=CC=3)(=O)=O)[CH:10]=2)[CH2:5][C:4]1=[O:27])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]3[O:26][CH2:14][CH:13]=[CH:12][C:9]=3[CH:10]=2)[CH2:5][C:4]1=[O:27])[CH3:2]参加物
4
実験手順
A mixture of 1.65 g. (4.41 mmoles) of 1-ethyl-5-hydroxy-6-(3-tosyloxypropyl)oxindole and 610 mg. (4.41 mmoles) of potassium carbonate in 90 ml. of acetone was heated at reflux for 2.5 hours. The reaction was cooled, filtered and the filtrate evaporated. The crude residue was purified by chromatographing on 100 g. of silica gel, using 66% diethyl ether-hexane as the eluent, to give 571 mg. (60% yield) of the desired intermediate.
後処理
- additionA mixture of 1.65 g
- temperatureat reflux for 2.5 hours
- temperatureThe reaction was cooled
- filtrationfiltered
- customthe filtrate evaporated
- customThe crude residue was purified by chromatographing on 100 g
- customto give 571 mg
出典と根拠
- ORDレコード
- ord-ddd2db1f5bb24722a2cbff509446ce72
- 出典データセット
- uspto-grants-1987_09
- 特許番号
- US04695571
反応ノート
読み込み中…