Einecs 211-027-4 → 2,6-Dimethyl-4-(3-methyl-1H-indol-2-yl)phenol

HRID 2309404ノート

反応式

HRID 2309404 の反応式
C[O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([C:10]2[NH:11][C:12]3[C:17]([C:18]=2[CH3:19])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:5][C:4]=1[CH3:20].[Cl-].[NH+]1C=CC=CC=1>O>[OH:2][C:3]1[C:4]([CH3:20])=[CH:5][C:6]([C:10]2[NH:11][C:12]3[C:17]([C:18]=2[CH3:19])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:7][C:8]=1[CH3:9]

参加物

4

反応物 2

HCID 69401Einecs 211-027-4HCID 136701412-(4-Methoxy-3,5-dimethylphenyl)-3-methylindole

生成物 1

HCID 136701422,6-Dimethyl-4-(3-methyl-1H-indol-2-yl)phenol収率 63.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4.3 g of 2-(4-methoxy-3,5-dimethylphenyl)-3-methylindole and 13 g of pyridinium chloride were reacted at 200° C. for 1.5 hours. The reaction mixture was cooled, poured into water, extracted with ethyl acetate, washed with water, and dried. The solvent was evaporated, and the residue was recrystallized from benzene-hexane to give 2.6 g of 2-(4-hydroxy-3,5-dimethylphenyl)-3-methylindole.

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with ethyl acetate
  3. washwashed with water
  4. customdried
  5. customThe solvent was evaporated
  6. customthe residue was recrystallized from benzene-hexane

出典と根拠

ORDレコード
ord-b3a29044874c44b495ff169bdfa34147
出典データセット
uspto-grants-1987_09
特許番号
US04695581

反応ノート

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