Diazomethane → Methyl 7-(2-oxocyclopentyl)heptanoate

HRID 2309559ノート

反応式

HRID 2309559 の反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[N+](=[CH2:18])=[N-]>CCOCC>[CH3:18][O:14][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

参加物

4

反応物 2

HCID 9550DiazomethaneHCID 989472-Oxocyclopentaneheptanoic acid

生成物 1

HCID 13099223Methyl 7-(2-oxocyclopentyl)heptanoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A 2.14 g. portion of 7-(2-oxocyclopentyl)-heptanoic acid was dissolved in 20 ml. of anhydrous ether and cooled to 0° C. in an ice bath. The stirred solution was then treated with ethereal diazomethane in about 1 ml. portions to control gas evolution until the yellow color persisted and bubbling was slow. The excess reagent was then blown off with a stream of nitrogen and the solvent evaporated at the rotovap. The residual oily ester was dried in vacuo over phosphorous pentoxide.

後処理

  1. custombubbling
  2. customthe solvent evaporated at the rotovap
  3. dry with materialThe residual oily ester was dried in vacuo over phosphorous pentoxide

出典と根拠

ORDレコード
ord-3f7f559b05714d5a81aa4dcef06c6133
出典データセット
uspto-grants-1987_09
特許番号
US04695647

反応ノート

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