Ethyl 3-amino-3-methylbutanoate → Ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate

HRID 2309678ノート

反応式

HRID 2309678 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]=[C:7]=[O:8].[NH2:9][C:10]([CH3:18])([CH3:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]>C(Cl)Cl>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([NH:9][C:10]([CH3:18])([CH3:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[O:8]

参加物

4

反応物 2

HCID 11480520Ethyl 3-amino-3-methylbutanoateHCID 149715841-Bromo-4-isocyanatobutane

生成物 1

HCID 20184474Ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate収率 95%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-20 °C

実験手順

A solution of 4-bromobutylisocyanate (15.1 g) in methylene chloride (50 ml) is added to a stirred solution of ethyl 3-amino-3-methylbutanoate (12.3 g), dissolved in methylene chloride (50 ml) at -20° C. The mixture is stirred for 30 minutes at -20° C. and then for an additional 2 hours at room temperature. Evaporation of the solvent yields a residue of ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate (26 g).

後処理

  1. waitfor an additional 2 hours at room temperature
  2. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-d021e12515424ff3a33414c07576d365
出典データセット
uspto-grants-1987_09
特許番号
US04696927

反応ノート

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