Piperidine → Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-

HRID 2309729ノート

反応式

HRID 2309729 の反応式
Cl.Cl[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:18]([CH:19]=1)=[N:17][C:16]1[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22]Cl)[CH:15]=1)[CH:10]=2.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:3][CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[C:18]([CH:19]=2)=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22][N:17]4[CH2:18][CH2:9][CH2:10][CH2:11][CH2:16]4)[CH:15]=2)[CH:10]=3)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

参加物

3

反応物 2

HCID 8082PiperidineHCID 201846653,6-Bis(2-chloroethoxy)acridine hydrochloride

生成物 1

HCID 133712Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-

実験手順

A suspension of 3,6-bis(2-chloroethoxy)acridine hydrochloride in piperidine was heated in a steel bomb at 80° C. for 24 hours. The excess piperidine was removed in vacuo and the residual solution was washed twice with 30 ml portions of saturated aqueous sodium bicarbonate, then dried and filtered. The filtrate was evaporated to a residue, giving 3,6-bis(2-piperidinoethoxy)acridine as yellow crystals, mp 129°-130° C.

後処理

  1. customThe excess piperidine was removed in vacuo
  2. washthe residual solution was washed twice with 30 ml portions of saturated aqueous sodium bicarbonate
  3. customdried
  4. filtrationfiltered
  5. customThe filtrate was evaporated to a residue

出典と根拠

ORDレコード
ord-89e4a6d9a2514b5bb1b8bdbf7803e153
出典データセット
uspto-grants-1987_09
特許番号
US04696936

反応ノート

読み込み中…