Water → 3,6-Dihydroxy-4,5-dimethylacridine

HRID 2309730

反応式

HRID 2309730 の反応式
[OH:1]C1C=CC2C(C=1)=NC1C(=CC=C(O)C=1)C=2.NC1C=CC2C(C=1)=NC1C(=CC=C(N)C=1)C=2.N[C:34]1[CH:35]=[CH:36][C:37]2[C:46]([C:47]=1[CH3:48])=[N:45][C:44]1[C:39](=[CH:40][CH:41]=[C:42](N)[C:43]=1[CH3:49])[CH:38]=2.S(=O)(=O)(O)O.[OH2:56]>>[OH:56][C:34]1[CH:35]=[CH:36][C:37]2[C:46]([C:47]=1[CH3:48])=[N:45][C:44]1[C:39](=[CH:40][CH:41]=[C:42]([OH:1])[C:43]=1[CH3:49])[CH:38]=2

参加物

6

反応物 5

HCID 962Water2 回HCID 1118Sulfuric AcidHCID 7099ProflavineHCID 38518Acridine, 3,6-diamino-4,5-dimethyl-HCID 135482596Acridine-3,6-diol

生成物 1

HCID 1358383693,6-Dihydroxy-4,5-dimethylacridine

実験手順

3,6-Dihydroxy-4,5-dimethylacridine is prepared by the procedure of Benda, L., Ber., 45, 1787 (1912), for the preparation of 3,6-dihydroxyacridine from 3,6-diaminoacridine. In this reaction 3,6-diamino-4,5-dimethylacridine is heated in a bomb with two parts of water and one part concentrated sulfuric acid at 200° C. for 8 hours. The reaction mixture is diluted with water and the crude solid collected by filtration. This material is purified by dissolution in excess 1N sodium hydroxide, followed by treatment with charcoal and then acidification with acetic acid, giving an orange solid.

後処理

  1. filtrationthe crude solid collected by filtration
  2. customThis material is purified by dissolution in excess 1N sodium hydroxide
  3. customacidification with acetic acid, giving an orange solid

出典と根拠

ORDレコード
ord-554ba3a361f4426ca723c67c867b6c1c
出典データセット
uspto-grants-1987_09
特許番号
US04696936

関連ノート

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