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Potassium Permanganate → 1-Phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Permanganate | HCID 516875 | — |
| 反応物 | 4-(2-Benzyl-1,3-thiazol-4-yl)pyridine | HCID 14096952 | — |
| 触媒 | Tetrahexylammonium iodide | HCID 75056 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanone | HCID 14096958 | 18.8% |
反応手順
To a mixture of 2-benzyl-4-(4-pyridyl)thiazole (3.00 g, 0.01 mol) and potassium permanganate (3.16 g, 0.02 mol) in benzene (30 mL) and water (60 mL) was added tetrahexyl ammonium iodide (0.96 g, 0.02 mol). The biphasic mixture was heated at reflux for 15 hours. After cooling the organic layer was separated and concentrated. The residue was taken up in ethyl acetate, filtered through silica gel, concentrated and chromatographed (ethyl acetate/hexane as eluant). Recrystallization from ethyl acetate/hexane afforded 1-phenyl-1-[4-(4-pyridyl)-2-thiazolyl]methanone (0.50 g, 11%). mp. 135°-136° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04697012 |
| 出典データセット | uspto-grants-1987_09 |
| ORD ID | ord-1cb6fdebe7074db480a459f0c84a1e37 |
| 出典メモ | uspto-grants-1987_09 |