2,3-Diaminopyridine → 2-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-imidazo[4,5-b]pyridine hydrochloride

HRID 2309860

反応式

HRID 2309860 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.NC1C=CC(C(O)=O)=C(OC)C=1.[NH2:28][C:29]1[C:34]([NH2:35])=[CH:33][CH:32]=[CH:31][N:30]=1>P(Cl)(Cl)(Cl)=O>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:35][C:34]2[C:29]([N:28]=1)=[N:30][CH:31]=[CH:32][CH:33]=2

参加物

5

反応物 3

HCID 99562,3-DiaminopyridineHCID 755994-Amino-o-anisic acidHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

生成物 1

HCID 201845172-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-imidazo[4,5-b]pyridine hydrochloride

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

反応条件

温度
80 °C

実験手順

Five grams of 2-methoxy-4-chlorosulfonyl-benzoic acid (prepared from 4-amino-2-methoxy-benzoic acid via the corresponding diazonium compound) were dissolved in 400 ml of phosphorus oxychloride and heated to 80° C. for 30 minutes. Then, 3.6 mg of 2,3-diaminopyridine were added, and the mixture was refluxed for four hours. The reaction mixture was concentrated by evaporation in vacuo and re-evaporated with toluene, and the solid residue was processed further without any other purification.

後処理

  1. temperaturethe mixture was refluxed for four hours
  2. concentrationThe reaction mixture was concentrated by evaporation in vacuo
  3. customre-evaporated with toluene
  4. customthe solid residue was processed further without any other purification

出典と根拠

ORDレコード
ord-5f3989f4c3714807afddf293f35354b6
出典データセット
uspto-grants-1987_09
特許番号
US04696931

関連ノート

読み込み中…