4,5-Diaminopyrimidine → 2-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

HRID 2309861ノート

反応式

HRID 2309861 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[NH2:16][C:17]1[C:22]([NH2:23])=[CH:21][N:20]=[CH:19][N:18]=1>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[N:16]=[C:17]2[C:22]([NH:23][CH:19]=[N:18]2)=[CH:21][N:20]=1

参加物

3

反応物 2

HCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

生成物 1

HCID 201845292-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

実験手順

Prepared analogously to Example C from 2.5 gm of 2-methoxy-4-chlorosulfonyl benzoic acid and 2.4 gm of 4,5-diamino-pyrimidine (crystalline product obtained from dihydrochloride and 1 mol of common salt) by refluxing for eight hours. The solid crude product was processed further without any purification.

後処理

  1. temperatureby refluxing for eight hours
  2. customThe solid crude product was processed further without any purification

出典と根拠

ORDレコード
ord-960828db7cb74670a598895fc7b94ba4
出典データセット
uspto-grants-1987_09
特許番号
US04696931

反応ノート

読み込み中…