Hydrochloric Acid → HCID 20184577、化合物

HRID 2309886ノート

反応式

HRID 2309886 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[CH3:16][NH2:17].[NH2:18][C:19]1[C:24]([NH2:25])=[CH:23][N:22]=[CH:21][N:20]=1.Cl>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([NH:17][CH3:16])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:25][C:24]2[C:19](=[N:20][CH:21]=[N:22][CH:23]=2)[N:18]=1

参加物

5

反応物 4

HCID 313Hydrochloric Acid2 回HCID 6329MethylamineHCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

生成物 1

HCID 20184577HCID 20184577、化合物

実験手順

Prepared analogously to Example 50 from 2-methoxy-4-chlorosulfonyl-benzoic acid, aqueous methylamine solution, and 4,5-diamino-pyrimidine. The crude free base was converted into the hydrochloride with 2N hydrochloride acid, and the hydrochloride was purified by boiling with methanol.

後処理

  1. customthe hydrochloride was purified

出典と根拠

ORDレコード
ord-7dccb0ae0f414ebabf152484547b1d01
出典データセット
uspto-grants-1987_09
特許番号
US04696931

反応ノート

読み込み中…