Sulfuric Acid → 5-Aminocarbonyl-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)benzimidazole

HRID 2309913ノート

反応式

HRID 2309913 の反応式
[C:1]([C:3]1[CH:24]=[CH:23][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][C:11]=3[O:21][CH3:22])[NH:9][C:5]=2[CH:4]=1)#[N:2].S(=O)(=O)(O)[OH:26]>>[NH2:2][C:1]([C:3]1[CH:24]=[CH:23][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([O:16][S:17]([CH3:20])(=[O:18])=[O:19])=[CH:12][C:11]=3[O:21][CH3:22])[NH:9][C:5]=2[CH:4]=1)=[O:26]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 201845285-Cyano-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole

生成物 1

HCID 201845645-Aminocarbonyl-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)benzimidazole

実験手順

One gram (2.91 mmol) of 5-cyano-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole was added batchwise to 15 ml of concentrated sulfuric acid, and the resulting mixture was stirred for 24 hours at ambient temperature. The solution was then poured onto 300 ml of ice water, and the product precipitated was subjected to suction filtration and recrystallized from methanol.

後処理

  1. customthe product precipitated
  2. filtrationwas subjected to suction filtration
  3. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-6acd20d33d334a2283b6bd807ca0b218
出典データセット
uspto-grants-1987_09
特許番号
US04696931

反応ノート

読み込み中…