Ibuprofen, (+-)- → Ibuprofen codeine

反応式

[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.[OH:23][C:24]([CH:26]([C:28]1[CH:37]=[CH:36][C:31]([CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:29]=1)[CH3:27])=[O:25]>>[OH:25][C:24]([CH:26]([C:28]1[CH:29]=[CH:30][C:31]([CH2:32][CH:33]([CH3:34])[CH3:35])=[CH:36][CH:37]=1)[CH3:27])=[O:23].[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1

参加物

反応物 2

HCID 3672Ibuprofen, (+-)-

HCID 5284371Codeine

生成物 1

HCID 9849057Ibuprofen codeine

実験手順

Codeine Phosphate, microcrystalline cellulose (Avicel PH102) and Starch 1500 were dry mixed. An aqueous solution of polyvinylpyrrolidone was then added to the dry powder and the mixture was granulated to give codeine granules. Microcrystalline cellulose (Avicel PH101) was then mixed with the granules. Finally, the codeine and ibuprofen granules were compressed to give an ibuprofen-codeine bilayer tablet with a crushing strength of 11-12 kp.

出典と根拠

ORDレコード: ord-59bd06f1bc794c6582feaf1dc95b8d04
出典データセット: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04844907

反応ノート

読み込み中…

参加物