化工社化工社 化学情報印刷レポート · 研究参考用
4-Hydroxybenzoic Acid → Benzoic acid, 4-hydroxy-, 2-methylbutyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxybenzoic Acid | HCID 135 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | (S)-2-methyl-1-butanol | HCID 2723602 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Benzoic acid, 4-hydroxy-, 2-methylbutyl ester | HCID 13530949 | 88.1% |
反応手順
0.29 mole(40.0 g) of 4-hydroxybenzoic acid and 0.35 mole(30.9 g) of (S)-(-)-2-methylbutanol were refluxed for 20 hours in 150 ml of toluene in the presence of 1 ml of conc. sulfuric acid. The reaction solution was concentrated, and then purified by column chromatography to obtain 53.2 g of 4-hydroxybenzoic acid 2-methylbutyl ester [[α]D23 =+4.95°(CHCl3)]. (yield: 88%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04844835 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-469b52153c964ebba05ae7f9953356b8 |
| 出典メモ | uspto-grants-1989_07 |