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Tetrahydrofuran → 4-Carbobenzoxyoxybenzoic acid 1-methylpropyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | (+)-2-Butanol | HCID 444683 | — |
| 反応物 | 4-Carbobenzoxyoxybenzoyl chloride | HCID 19734054 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-Carbobenzoxyoxybenzoic acid 1-methylpropyl ester | HCID 54239335 | 18% |
反応手順
A THF solution of 0.1 mole of (S)-(+)-2-butanol and 0.1 mole of triethylamine was stirred at 0° C., and a THF solution of 0.12 mole of 4-carbobenzoxyoxybenzoic acid chloride was added dropwise. The temperature was returned to the room temperature slowly, and stirring was carried out for 8 hours. After the reaction, the reaction solution was ether extracted, dried, concentrated, and purified by column chromatography, to obtain 5.7 g of 4-carbobenzoxyoxybenzoic acid 1-methylpropyl ester. (yield: 18%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04844835 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-86097eb86030476ead30188bc7baee4f |
| 出典メモ | uspto-grants-1989_07 |