Tetrahydrofuran → 4-Carbobenzoxyoxybenzoic acid 1-methylpropyl ester

HRID 231021

反応式

HRID 231021 の反応式
C1COCC1.[CH3:6][C@H:7]([OH:10])[CH2:8][CH3:9].C(N(CC)CC)C.[C:18]([O:28][C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1)([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19]>CCOCC>[CH3:6][CH:7]([O:10][C:33](=[O:34])[C:32]1[CH:31]=[CH:30][C:29]([O:28][C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:19])=[CH:37][CH:36]=1)[CH2:8][CH3:9]

参加物

6

反応物 4

HCID 8028Tetrahydrofuran2 回HCID 8471TriethylamineHCID 444683(+)-2-ButanolHCID 197340544-Carbobenzoxyoxybenzoyl chloride

生成物 1

HCID 542393354-Carbobenzoxyoxybenzoic acid 1-methylpropyl ester収率 18%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A THF solution of 0.1 mole of (S)-(+)-2-butanol and 0.1 mole of triethylamine was stirred at 0° C., and a THF solution of 0.12 mole of 4-carbobenzoxyoxybenzoic acid chloride was added dropwise. The temperature was returned to the room temperature slowly, and stirring was carried out for 8 hours. After the reaction, the reaction solution was ether extracted, dried, concentrated, and purified by column chromatography, to obtain 5.7 g of 4-carbobenzoxyoxybenzoic acid 1-methylpropyl ester. (yield: 18%)

後処理

  1. customwas returned to the room temperature
  2. customAfter the reaction
  3. extractionextracted
  4. customdried
  5. concentrationconcentrated
  6. custompurified by column chromatography

出典と根拠

ORDレコード
ord-86097eb86030476ead30188bc7baee4f
出典データセット
uspto-grants-1989_07
特許番号
US04844835

関連ノート

読み込み中…