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HRID 231038作成日：2026年10月27日
2-(Bis(methylsulfanyl)methylidene)propanedinitrile → 5-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazole
https://huagongshe.com/reaction/231038
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(Bis(methylsulfanyl)methylidene)propanedinitrile | HCID 99229 | — |
| 反応物 | ((3-(Trifluoromethyl)phenyl)methyl)hydrazine | HCID 599698 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazole | HCID 14071022 | 80% |
反応手順
8.5 g of 1,1-dicyano-2,2-bis-(methylmercapto)-ethylene and 9.5 g of 3-trifluoromethyl-benzylhydrazine are mixed in 100 ml of ethanol. The mixture is stirred for 15 hours at 20° C. and the solvent is evaporated in a rotary evaporator. The residue is triturated in petroleum ether. 12.4 g (80% of theory) of 1-(3-trifluoromethylbenzyl)-3-methylmercapto-4-cyano-5-amino-pyrazol of melting point 142° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04845089 |
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| 出典データセット | uspto-grants-1989_07 |
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| ORD ID | ord-2bb6033b34274278a7fe1a46953b216c |
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| 出典メモ | uspto-grants-1989_07 |
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