Sodium Dithionite → 4-chloro-3-hydroxy-10H-phenothiazine

HRID 231042

反応式

HRID 231042 の反応式
[O-]S(S([O-])=O)=O.[Na+].[Na+].[Cl:9][C:10]1[C:11](=[O:24])[CH:12]=[CH:13][C:14]2[C:23]=1[S:22][C:21]1[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=1)[N:15]=2>O.CN(C=O)C>[Cl:9][C:10]1[C:23]2[S:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][C:14]=2[CH:13]=[CH:12][C:11]=1[OH:24]

参加物

5

反応物 2

HCID 24489Sodium DithioniteHCID 117767483H-Phenothiazin-3-one, 4-chloro-

生成物 1

HCID 98814184-chloro-3-hydroxy-10H-phenothiazine収率 95%

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 6228Dimethylformamide溶媒

実験手順

A solution of Na2S2O4 (70 g) in water (500 ml) was added to a solution of 4-chloro-3H-phenothiazin-3-one (50 g) in DMF (1200 ml). The reaction mixture was stirred at room temperature for 3 hours and then poured in 5 liters of water. The resulting precipitate was then filtered to give the 4-chloro-3-hydroxy-10H-phenothiazine (95 %). m.p.: 110° C.

後処理

  1. filtrationThe resulting precipitate was then filtered

出典と根拠

ORDレコード
ord-a8e0a4ea15384cfcba7a021ba85692e7
出典データセット
uspto-grants-1989_07
特許番号
US04845083

関連ノート

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