Water → 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

HRID 231049ノート

反応式

HRID 231049 の反応式
[Cl:1][C:2]1[C:15]2[S:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[OH:16].[C:17](Cl)(=[O:19])[CH3:18].C(OCC)(=O)C.O>CN(C=O)C>[C:17]([N:7]1[C:6]2[CH:5]=[CH:4][C:3]([OH:16])=[C:2]([Cl:1])[C:15]=2[S:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)(=[O:19])[CH3:18]

参加物

6

反応物 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8857Ethyl AcetateHCID 98814184-chloro-3-hydroxy-10H-phenothiazine

生成物 1

HCID 1388203310-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 4-chloro-3-hydroxyphenothiazine (2.2 g) in DMF (10 ml) was added 10 ml of acetyl chloride. The reaction mixture was stirred at ambient temperature for 1 hour. Ethyl acetate was then added, followed by ice and H2O. The organic layer was separated, dried and evaporated. The resulting residue was purified by chromatography on silica gel to give 1.4 g of 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine (m.p. 214° C.).

後処理

  1. customThe organic layer was separated
  2. customdried
  3. customevaporated
  4. customThe resulting residue was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-1c5ba483752c45b6afffabc345b90f0c
出典データセット
uspto-grants-1989_07
特許番号
US04845083

反応ノート

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