Aniline → HCID 13568664、化合物
反応式
O1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)=[O:8])[CH2:3][CH2:2]1.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([N:20]2[CH2:6][CH2:5][N:4]([C:7]([C:9]3[CH:10]=[C:11]4[C:16](=[CH:17][CH:18]=3)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]4)=[O:8])[CH2:3][CH2:2]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1参加物
3
実験手順
2.62 Grams of 6-morpholinocarbonyl-3,4-dihydrocarbostyril and 10 g of aniline were placed in a sealed tube and heated at 170°-200° C. for 5 hours. Excess aniline was removed by evaporation under reduced pressure, then the residue thus obtained was purified by means of silica gel column chromatography. Recrystallized from isopropanol to obtain 0.32 g of 6-(4-phenyl-1-piperazinylcarbonyl)-3,4-dihydrocarbostyril. Colorless needle-like crystals. Melting point: 200°-201° C.
後処理
- temperatureheated at 170°-200° C. for 5 hours
- customExcess aniline was removed by evaporation under reduced pressure
- customthe residue thus obtained
- customwas purified by means of silica gel column chromatography