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4-Bromo-3-methylaniline → N-([(4-bromo-3-methylphenyl)amino]carbonyl)-4-methylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-3-methylaniline | HCID 23359 | — |
| 反応物 | p-Toluenesulfonyl isocyanate | HCID 77703 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-([(4-bromo-3-methylphenyl)amino]carbonyl)-4-methylbenzenesulfonamide | HCID 2375417 | 80% |
反応手順
A solution of 5.58 g of 4-bromo-3-methylaniline in 20 ml of toluene and 5 ml of methylene chloride was added to a solution of 5.91 g of p-toluenesulfonyl isocyanate in 50 ml of toluene and 10 ml of methylene chloride under a nitrogen atmosphere. The mixture was stirred overnight and filtered, providing 9.19 g of the title product, m.p. 178°-180° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04845128 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-834add1636a0446ba63de4f00a344356 |
| 出典メモ | uspto-grants-1989_07 |