Cyclopentylacetic acid → N-(cyclopentylacetyl)-L-alanine Iso-butyl Ester
反応式
[CH:1]1([CH2:6][C:7]([OH:9])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH2:18])[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH:18][C:7](=[O:9])[CH2:6][CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)[CH:12]([CH3:14])[CH3:13]参加物
3
実験手順
Following General Procedure BB above, and using cyclopentylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 62° C.-64° C. The reaction was monitored by tlc on silica gel (Rf=0.37 in 1:3 EtOAc:hexane) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
後処理
- customThe reaction was monitored by tlc on silica gel (Rf=0.37 in 1:3 EtOAc:hexane) and purification
- extractionwas by extraction with Et2O
出典と根拠
- ORDレコード
- ord-759f28cc195f45dcac582d3bf1a38aaf
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849650B2
反応ノート
読み込み中…