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Hydrochloric Acid → 2-Acetyl-4-methoxycyclohexanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Methoxycyclohexanone | HCID 535028 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Acetyl-4-methoxycyclohexanone | HCID 13632724 | 43.2% |
反応手順
To 2.5 g of ethyl acetate was added 1.12 g of 60% sodium hydride and, a solution of 1.78 g of 4-methoxycyclohexanone in benzene was added to the mixture. After reacting at 40° C. for 3 hours, methanol was added to decompose an excess of sodium hydride, which was poured into water. The mixture was neutralized with hydrochloric acid ahd extracted with ether to give 1.02 g of 2-acetyl-4-methoxycyclohexanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04845228 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-be6ece670b8f49489d05b7e0c43e9ab9 |
| 出典メモ | uspto-grants-1989_07 |