trans-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone → trans-4-Acetoxy-3-(1-hydroxyethyl)-2-azetidinone

HRID 231231ノート

反応式

HRID 231231 の反応式
[C:1]([O:4][C@@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[CH:10]([O:12][Si](C(C)(C)C)(C)C)[CH3:11])(=[O:3])[CH3:2]>C(O)(=O)C.O>[C:1]([O:4][C@@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[CH:10]([OH:12])[CH3:11])(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 67757824trans-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

生成物 1

HCID 67789253trans-4-Acetoxy-3-(1-hydroxyethyl)-2-azetidinone収率 24.9%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

Trans-4-acetoxy-3-[1-(tert-butyldimethylsilyloxy)-ethyl]-2-azetidinone (0.20 g) is dissolved in a mixture of acetic acid (5 ml) and water (2 ml), and the solution is stirred at 70°-80° C. for 2.5 hours and then concentrated under reduced pressure. The residue is subjected to silica gel column chromatography to give 0.03 g of trans-4-acetoxy-3-(1-hydroxyethyl)-2-azetidinone.

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d0ad439e23884e80974957d04dd3358d
出典データセット
uspto-grants-1989_07
特許番号
US04845210

反応ノート

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