Dichloromethane → 2-Methoxy-3-octadecyloxypropyl methanesulfonate

HRID 231255

反応式

HRID 231255 の反応式
ClCCl.[CH3:4][O:5][CH:6]([CH2:9][O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:7][OH:8].[CH3:29][S:30](Cl)(=[O:32])=[O:31]>C(N(CC)CC)C>[CH3:29][S:30]([O:8][CH2:7][CH:6]([O:5][CH3:4])[CH2:9][O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])(=[O:32])=[O:31]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 3364221-Propanol, 2-methoxy-3-(octadecyloxy)-

生成物 1

HCID 145010372-Methoxy-3-octadecyloxypropyl methanesulfonate収率 100%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To 120 ml of dichloromethane are added 12.0 g of 2-methoxy-3-octadecyloxypropanol and 6.07 ml of triethylamine, to which 4.98 g of methanesulfonyl chloride is added dropwise with stirring under ice cooling. Thereafter, the mixture is stirred at room temperature for 2 hours to complete the reaction. The reaction mixture is then washed with water, an aqueous sodium bicarbonate solution and again water and dried over anhydrous sodium sulfate. The solvent is distilled off under reduced pressure to leave 14.6 g (100%) of the captioned compound.

後処理

  1. stirringThereafter, the mixture is stirred at room temperature for 2 hours
  2. customthe reaction
  3. washThe reaction mixture is then washed with water
  4. dry with materialan aqueous sodium bicarbonate solution and again water and dried over anhydrous sodium sulfate
  5. distillationThe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-0463feb32d9745479a5b23a92d5682b6
出典データセット
uspto-grants-1989_07
特許番号
US04845219

関連ノート

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