Triethylamine → 3-Mesyloxypropyl 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl sulfone

HRID 231272ノート

反応式

HRID 231272 の反応式
[OH:1][CH2:2][CH2:3][CH2:4][S:5]([CH2:8][CH:9]([O:30][CH3:31])[CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)(=[O:7])=[O:6].C(N(CC)CC)C.[CH3:39][S:40](Cl)(=[O:42])=[O:41]>ClCCl>[CH3:31][O:30][CH:9]([CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1)[CH2:8][S:5]([CH2:4][CH2:3][CH2:2][O:1][S:40]([CH3:39])(=[O:42])=[O:41])(=[O:7])=[O:6]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 536553312-Methoxy-3-(12-cyclohexyldodecyloxy)propyl 3-hydroxypropyl sulfone

生成物 1

HCID 200348483-Mesyloxypropyl 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl sulfone収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In 100 ml of dichloromethane are dissolved 8.9 g of 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl 3-hydroxypropyl sulfone and 3.7 ml of triethylamine, to which 3.0 g of methanesulfonyl chloride is added dropwise with stirring under ice cooling. After 2 hours stirring at room temperature, the reaction solution is washed with water, an aqueous sodium bicarbonate solution and water, and dried. The solvent is then distilled off under reduced pressure to leave 10.4 g of the captioned compound.

後処理

  1. stirringAfter 2 hours stirring at room temperature
  2. washthe reaction solution is washed with water
  3. dry with materialan aqueous sodium bicarbonate solution and water, and dried
  4. distillationThe solvent is then distilled off under reduced pressure

出典と根拠

ORDレコード
ord-7b72b371a23642eb80240b8937b93466
出典データセット
uspto-grants-1989_07
特許番号
US04845219

反応ノート

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