Aniline → 4-Phenyl-3,4-dihydroquinolin-2(1h)-one

HRID 23129

反応式

HRID 23129 の反応式
[C:1](Cl)(=[O:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:4]1([CH:3]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12][C:1](=[O:10])[CH2:2]2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

3

反応物 2

HCID 6115AnilineHCID 660233-Phenylprop-2-enoyl chloride

生成物 1

HCID 2725094-Phenyl-3,4-dihydroquinolin-2(1h)-one

実験手順

4-Phenyl-3,4-dihydrocarbostyril (CAS# 4888-33-9) was prepared in two steps using the procedure described by Conley, R. T.; Knopka. W. N. J. Org. Chem. 1964, 29, 496-497. The starting materials for this preparation were cinnamoyl chloride (Aldrich) and aniline (Aldrich). The title compound was purified by flash chromatography eluting with CH2Cl2/EtOAc (4:1).

後処理

  1. customThe title compound was purified by flash chromatography
  2. washeluting with CH2Cl2/EtOAc (4:1)

出典と根拠

ORDレコード
ord-eb44577bef4346a1b15aac443b94e8bc
出典データセット
uspto-grants-2005_02
特許番号
US06849650B2

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