関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Isobutyl iodide | HCID 10556 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 5-(N-Boc-amino)-5,7-dihydro-6H-dibez[b,d]azepin-6-one | HCID 11493548 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Amino7-(2-methylpropyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one Hydrochloride | HCID 22288314 | — |
反応手順
A solution of 5-(N-Boc-amino)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (0.2 g, 0.617 mmol) (Example 7-E) in DMF was treated with Cs2CO3 (0.22 g, 0.678 mmol) and warmed to 60° C. To the reaction mixture was added 1-iodo-2-methylpropane (0.078 ml, 0.678 mmol) and stirring continued for 17 h. After cooling to 23° C. the mixture was diluted with CH2Cl2, washed with several portions of brine and dried over Na2SO4. The title compound was purified by chromatography (SiO2, CHCl3/MeOH 9:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06849650B2 |
|---|
| 出典データセット | uspto-grants-2005_02 |
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| ORD ID | ord-7aeb8ae534b34973b7a463f3df84db89 |
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| 出典メモ | uspto-grants-2005_02 |
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