Ammonia → HCID 19980851、化合物

HRID 231347ノート

反応式

HRID 231347 の反応式
[NH3:1].O=[C:3]([CH3:11])[CH2:4][C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]>C(O)C>[NH2:1]/[C:3](/[CH3:11])=[CH:4]\[C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]

参加物

4

反応物 2

HCID 222AmmoniaHCID 118544Butanoic acid, 3-oxo-, 2-hydroxyethyl ester

生成物 1

HCID 19980851HCID 19980851、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Anhydrous ammonia gas was bubbled through a solution of 2-hydroxyethyl 3-oxo-butyrate (25 g, 0.17 moles) (ref 5) and ethanol (250 mL) for 20 minutes. This solution was stirred for 16 hours at room temperature. The solvent was removed in vacuo and the resulting oil was chromatographed on silica gel (250 g) using ethyl acetate-hexane 60:40 as eluant. The enriched fractions were combined and the solvent removed in vacuo to give the product; H' NMR CDCl3 4.33 (t, 2H) 3.85 (t, 2H) 3.55 (s, 1H) 2.85 (broad singlet, 1H) 2.31 (s, 3H).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe resulting oil was chromatographed on silica gel (250 g)
  3. customthe solvent removed in vacuo
  4. customto give the product

出典と根拠

ORDレコード
ord-de4688cb7e324f85aadd3014ecce9c53
出典データセット
uspto-grants-1989_07
特許番号
US04845225

反応ノート

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