Potassium Hydroxide → 1-Cyano-3-methylcyclohexane-1-carboxylic acid

反応式

[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][C:4]([C:13]#[N:14])([C:8]([O:10]CC)=[O:9])[CH2:3]1.[OH-].[K+]>>[C:13]([C:4]1([C:8]([OH:10])=[O:9])[CH2:5][CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3]1)#[N:14]

参加物

反応物 2

HCID 14797Potassium Hydroxide

HCID 20032648Ethyl 3-methyl-1-cyanocyclohexanecarboxylate

生成物 1

HCID 198007731-Cyano-3-methylcyclohexane-1-carboxylic acid

実験手順

This ester is hydrolyzed by heating with ethanolic potassium hydroxide solution. Neutralization, extraction with methyl tert.-butyl ether and distillative removal of the solvent gives 1-cyano-3-methylcyclohexanecarboxylic acid.

後処理

extractionNeutralization, extraction
customwith methyl tert.-butyl ether and distillative removal of the solvent

出典と根拠

ORDレコード: ord-2cd216ae7bb34f7280dc83604263c364
出典データセット: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04846998

反応ノート

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