Water → Ethyl 1-isopentyl-4-nitro-1H-pyrrole-2-carboxylate

HRID 23146

反応式

HRID 23146 の反応式
[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)=[O:5])[CH3:2].[O-]CC.[Na+].Br[CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22].O>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)=[O:5])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 78911-Bromo-3-methylbutaneHCID 242169Ethyl 4-Nitropyrrole-2-carboxylateHCID 2723922Sodium ethoxide

生成物 1

HCID 67183320Ethyl 1-isopentyl-4-nitro-1H-pyrrole-2-carboxylate収率 29%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

4-Nitro-1H-pyrrole-2-carboxylic acid ethyl ester (3.69 g, 20.04 mmol) was dissolved in 100 ml of hot anhydrous ethanol and the solution was cooled to room temperature. 30 ml of sodium ethoxide (about 1M) in ethanol was added. The reaction mixture was stirred at room temperature for 20 min and 1-bromo-3-methylbutane (8 ml) was added. The mixture was stirred at reflux for 6 h and cooled to room temperature and then poured into water. The pale yellow precipitates were collected by filtration, washed with water, and dried to give the product (1.48 g, 29%).

後処理

  1. stirringThe mixture was stirred
  2. temperatureat reflux for 6 h
  3. temperaturecooled to room temperature
  4. customThe pale yellow precipitates
  5. filtrationwere collected by filtration
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-69759c971e2e427683be49f0c87c3811
出典データセット
uspto-grants-2005_02
特許番号
US06849713B2

関連ノート

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