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Dicyclohexylcarbodiimide → 4'-Hexylbiphenyl-4-yl 1-cyano-3-methylcyclohex-anecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 4-Diethylaminopyridine | HCID 11768751 | — |
| 反応物 | 4'-Hexyl-biphenyl-4-ol | HCID 13574860 | — |
| 反応物 | 1-Cyano-3-methylcyclohexane-1-carboxylic acid | HCID 19800773 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4'-Hexylbiphenyl-4-yl 1-cyano-3-methylcyclohex-anecarboxylate | HCID 19800761 | — |
反応手順
A solution of 23 g of dicyclohexylcarbodiimide in 50 ml of CH2Cl2 is added at room temperature to a mixture of 16 g of 1-cyano-3-methyl-cyclohexanecarboxylic acid, 25 g of 4'-hexylbiphenyl-4-ol, 1.2 g of 4-diethylaminopyridine and 200 ml of methylene chloride, and the mixture is stirred for 2 hours. Customary working up and separation by column chromatography (silica gel/toluene) and recrystallization gives the pure product 4'-hexylbiphenyl-4-yl 1-cyano-3-methylcyclohex-anecarboxylate, m.p. 51°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04846998 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-654df5f5c24c4203a7fcaa89aacdf3b9 |
| 出典メモ | uspto-grants-1989_07 |