Dimethylformamide dimethyl acetal → 3'-Chloro-3-dimethylamino-2-methylacrylophenone
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH2:9][CH3:10])[CH:5]=[CH:6][CH:7]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[C:9]([CH3:10])=[CH:14][N:15]([CH3:16])[CH3:17])[CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
A mixture of 75.0 g of m-chloropropiophenone and 200 ml of N,N-dimethylformamide dimethyl acetal was stirred and heated at reflux for 16 hours. The mixture was evaporated in vacuo to give a black oil. The oil was subjected to Kugelrohr distillation at 0.5 mm of mercury and the fraction that boils at 110° C. was removed. The residue from the distillation was collected to give 35.0 g of 3'-chloro-3-dimethylamino-2-methylacrylophenone as a black oil.
後処理
- temperatureheated
- temperatureat reflux for 16 hours
- customThe mixture was evaporated in vacuo
- customto give a black oil
- distillationThe oil was subjected to Kugelrohr distillation at 0.5 mm of mercury
- customthe fraction that boils at 110° C. was removed
- distillationThe residue from the distillation
- customwas collected
出典と根拠
- ORDレコード
- ord-8d16c1f36b8c45f6b1a124928cf6bdc6
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04847256
反応ノート
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