4,6-Nonanedione → 2-Methyl-5,7-dipropylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 231520

反応式

HRID 231520 の反応式
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]#[N:9].[CH3:10][CH2:11][CH2:12][C:13](=O)[CH2:14][C:15](=O)[CH2:16][CH2:17][CH3:18]>C(O)(=O)C>[CH3:7][C:4]1[C:3]([C:8]#[N:9])=[C:2]2[N:1]=[C:13]([CH2:12][CH2:11][CH3:10])[CH:14]=[C:15]([CH2:16][CH2:17][CH3:18])[N:6]2[N:5]=1

参加物

4

反応物 2

HCID 264544,6-NonanedioneHCID 178434678HCID 178434678、化合物

生成物 1

HCID 145018642-Methyl-5,7-dipropylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A stirred mixture of 4.88 g of 5-amino-3-methylpyrazole-4-carbonitrile and 6.25 g of 4,6-nonanedione in 50 ml of glacial acetic acid was heated at reflux for 10 hours. The reaction mixture after reflux was worked up as described in Example 50 to give 7.80 of 2-methyl-5,7-dipropylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, mp 73°-74° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 10 hours
  3. temperatureThe reaction mixture after reflux

出典と根拠

ORDレコード
ord-89c615348933471da2cd3e9a21c3df0d
出典データセット
uspto-grants-1989_07
特許番号
US04847256

関連ノート

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