Bromine → 3-Bromo-5-chloropyridin-2-amine

HRID 231531

反応式

HRID 231531 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[Br:9]Br>C(Cl)Cl>[NH2:1][C:2]1[C:7]([Br:9])=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 24408BromineHCID 661742-Amino-5-chloropyridine

生成物 1

HCID 27639713-Bromo-5-chloropyridin-2-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

20 g (77.8 mmol) of 2-amino-5-chloropyridine dissolved in 160 ml of CH2Cl2 are reacted with 8 ml of bromine, which is added dropwise at 0° C. After the addition is complete, the mixture is left to react at 25° C. for 2 h. The suspension is washed with 10% strength sodium hydroxide solution, and the organic phase is washed with water and then dried over MgSO4, filtered and evaporated. The compound obtained is recrystallized in isopropanol. M.p. 82° C.

後処理

  1. additionis added dropwise at 0° C
  2. additionAfter the addition
  3. waitthe mixture is left
  4. customto react at 25° C. for 2 h
  5. washThe suspension is washed with 10% strength sodium hydroxide solution
  6. washthe organic phase is washed with water
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. customevaporated
  10. customThe compound obtained
  11. customis recrystallized in isopropanol

出典と根拠

ORDレコード
ord-3451f38d55ba4813800da4d87e3bf5b8
出典データセット
uspto-grants-1989_07
特許番号
US04847263

関連ノート

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