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p-Chlorophenacyl bromide → 8-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Chlorophenacyl bromide | HCID 68303 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 3-Bromo-5-chloropyridin-2-amine | HCID 2763971 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 8-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine | HCID 14234917 | — |
反応手順
17 g (82 mmol) of 2-amino-3-bromo-5-chloropyridine dissolved in 150 ml of ethanol are reacted with 29 g of 2-bromo-1-(4-chlorophenyl)-1-ethanone and 14 g of sodium hydrogen carbonate. The mixture is brought to the refluxing temperature for 6 h and cooled. The precipitate is filtered off and rinsed with CH2Cl2, and the filtrate is concentrated under reduced pressure. After recrystallization of the evaporation residue in ethyl acetate, the compound melts at 178° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04847263 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-8a2f27f02afd4b7b85817dfa22b20cfb |
| 出典メモ | uspto-grants-1989_07 |