化工社化工社 化学情報印刷レポート · 研究参考用
N,N-Dimethylethylenediamine → N-[2-(dimethylamino)ethyl]-6-nitro-1H-indole-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylethylenediamine | HCID 66053 | — |
| 反応物 | Methyl 6-nitro-1H-indole-2-carboxylate | HCID 11816863 | — |
| 生成物 | N-[2-(dimethylamino)ethyl]-6-nitro-1H-indole-2-carboxamide | HCID 85801420 | 84% |
反応手順
500 mg (2.27 mmole) 6-Nitro-1H-indole-2-carboxylic acid methyl ester was dissolved in 4 mL neat N1,N1-dimethyl-ethane-1,2-diamine, was kept at 55° C. overnight and was evaporated. The oily residue was triturated with n-hexane to give 528 mg (84%) yellow solid which was no further purified. MS: 277.13 (calcd for M+H+:277.13)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849713B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-437bfcf42a734cadaba4bc4b65654239 |
| 出典メモ | uspto-grants-2005_02 |