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Diethyl Sulfate → Ethyl 2-amino-6-nitrobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Sulfate | HCID 6163 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Amino-6-nitro-benzoic acid | HCID 95795 | — |
| 生成物 | Ethyl 2-amino-6-nitrobenzoate | HCID 20033751 | — |
反応手順
A solution of 2-amino-6-nitrobenzoic acid (29.2 g, 0.16 mol), diethylsulfate (24.7 g, 0.160 mol) and triethylamine (16.2 g, 0.160 mol) in N-dimethylformamide (250 ml) was stirred at 20-25° for 20 hours. After removing DMF at 60° and 0.2 mm pressure, the residue was flash chromotographed over silica gel and the ethyl ester (10.8 g) eluted first with toluene then with 50% toluene-50% chloroform.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04847294 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-c2b21851377d4ef093985a94dcaa0ab0 |
| 出典メモ | uspto-grants-1989_07 |