Potassium Hydroxide → HCID 20033693、化合物

HRID 231679

反応式

HRID 231679 の反応式
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[OH-].[K+].Br[C:15]1[S:19][C:18]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:17][CH:16]=1>CN(C)C=O.O>[C:9]([CH2:8][C:5]1[CH:4]=[CH:3][C:2]([S:1][C:15]2[S:19][C:18]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:17][CH:16]=2)=[CH:7][CH:6]=1)([OH:11])=[O:10]

参加物

6

反応物 3

HCID 14797Potassium HydroxideHCID 12413045-Bromo-2-thiophenesulfonamideHCID 33905114-Mercaptophenylacetic acid

生成物 1

HCID 20033693HCID 20033693、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
120 °C

実験手順

4-Mercaptophenylacetic acid (2.3 g) was dissolved in dimethylformamide under a nitrogen atmosphere and 1.8 g of potassium hydroxide dissolved in a minimum amount of water was added. 5-bromothiophene-2-sulfonamide (3.3 g) dissolved in dimethylformamide was added and the mixture heated at 120° C. for 2 hours. After cooling to room temperature water was added to the reaction mixture, the pH was adjusted to 8.6 and the mixture was extracted with ethyl acetate. The aqueous phase was separated and acidified, causing a solid to precipitate. The solid was collected by filtration and dried under vacuum to a weight of 3.25 g.

後処理

  1. additionwas added
  2. additionwas added
  3. additionwas added to the reaction mixture
  4. extractionthe mixture was extracted with ethyl acetate
  5. customThe aqueous phase was separated
  6. customto precipitate
  7. filtrationThe solid was collected by filtration
  8. customdried under vacuum to a weight of 3.25 g

出典と根拠

ORDレコード
ord-e9ec0aeb8d5c4266906869950d3ea639
出典データセット
uspto-grants-1989_07
特許番号
US04847289

関連ノート

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