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Diazomethane → 2-(2,4-Dichlorobenzoyl)-2-(2,4-dichlorophenyl)oxirane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diazomethane | HCID 9550 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Urea, (nitrosomethyl)- | HCID 104823 | — |
| 反応物 | 1,2-Bis(2,4-dichlorophenyl)ethane-1,2-dione | HCID 13391683 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-(2,4-Dichlorobenzoyl)-2-(2,4-dichlorophenyl)oxirane | HCID 19870083 | — |
反応手順
With cooling and stirring, an ethereal diazomethane solution prepared from 3.1 g of nitrosomethylurea and aqueous sodium hydroxide solution in ether is added dropwise to a solution of 3.4 g of 2,2',4,4'-tetrachlorobenzil in 50 ml of dioxane. When the dropwise addition is complete, stirring is continued for 16 hours at room temperature, and the reaction mixture is then concentrated to dryness. The residual oil is crude 2-(2,4-dichlorobenzoyl)-2-(2,4-dichlorophenyl)oxirane which is purified by high vacuum distillation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04849007 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-068a47997e2c45ea9953c3a15c70f647 |
| 出典メモ | uspto-grants-1989_07 |