2-Chloropyrimidine → 3-[4-(Pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol

HRID 231762ノート

反応式

HRID 231762 の反応式
[OH:1][CH:2]([CH2:10][OH:11])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.Cl[C:13]1[N:18]=[CH:17][CH:16]=[CH:15][N:14]=1>O1CCOCC1>[N:14]1[CH:15]=[CH:16][CH:17]=[N:18][C:13]=1[N:7]1[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][OH:11])[CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 744042-ChloropyrimidineHCID 1110023-(Piperazin-1-yl)propane-1,2-diol

生成物 1

HCID 200319993-[4-(Pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Grams 3.2 of 1-(2,3-dihydroxypropyl)piperazine and 1.14 g of 2-chloropyrimidine in 50 ml dioxane were refluxed for two and a half hour. The reaction mixture was then settled and the solution evaporated to dryness. The residue obtained was extracted with hot acetone and filtered to remove all impurities. After resting 1.1 g of 3-[4-(pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol were separated, which melted at 118°-120° C.

後処理

  1. customthe solution evaporated to dryness
  2. customThe residue obtained
  3. extractionwas extracted with hot acetone
  4. filtrationfiltered
  5. customto remove all impurities
  6. customwere separated

出典と根拠

ORDレコード
ord-25bdf0bbd7a74db187d6766b64822a0d
出典データセット
uspto-grants-1989_07
特許番号
US04849422

反応ノート

読み込み中…