3,6-Dichloropyridazine → 3-[4-(6-Chloropyridazin-3-yl)piperazin-1-yl]propane-1,2-diol
反応式
[OH:1][CH:2]([CH2:10][OH:11])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[Cl:12][C:13]1[N:14]=[N:15][C:16](Cl)=[CH:17][CH:18]=1>C(O)(C)C>[Cl:12][C:13]1[N:14]=[N:15][C:16]([N:7]2[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][OH:11])[CH2:5][CH2:6]2)=[CH:17][CH:18]=1参加物
4
実験手順
Grams 32 of 1-(2,3-dihydroxypropyl)piperazine and 15 g of 3,6-dichloropyridazine in 700 ml isopropanol were refluxed for 24 hours. The reaction mixture was settled, the solid undissolvable removed and the solution evaporated to dryness. The so obtained residue was purified on column eluting with chloroform:methanol (9:1). Grams 2.1 of 3-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]propane-1,2-diol, which, recrystallized from acetone, melted at 126°-128° C.