2-Chloronicotinamide → 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinamide
反応式
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[OH:11][CH:12]([CH2:20][OH:21])[CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(O)C>[OH:11][CH:12]([CH2:20][OH:21])[CH2:13][N:14]1[CH2:19][CH2:18][N:17]([C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([NH2:6])=[O:5])[CH2:16][CH2:15]1参加物
4
実験手順
Operation was carried out in a manner similar to the one described in Example 2, using 1.6 g of 2-chloronicotinamide, 3.2 g of 1-(2,3-dihydroxypropyl)piperazine and 30 ml ethanol and refluxing overnight. Column purification of the residue gave 1 g of 2-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinamide, which, recrystallized from acetone, melted at 140°-142° C.
後処理
- temperaturerefluxing overnight
- customColumn purification of the residue
出典と根拠
- ORDレコード
- ord-0ef617aa10c541aea1bf538ef375577c
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04849422
反応ノート
読み込み中…