2-Chloropyridine → 3-[4-(Pyridin-2-yl) piperazin-1-yl]propane-1,2-diol dihydrochloride

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[OH:8][CH:9]([CH2:17][OH:18])[CH2:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[ClH:1].[ClH:1].[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:14]1[CH2:13][CH2:12][N:11]([CH2:10][CH:9]([OH:8])[CH2:17][OH:18])[CH2:16][CH2:15]1

参加物

反応物 2

HCID 79772-Chloropyridine

HCID 1110023-(Piperazin-1-yl)propane-1,2-diol

生成物 1

HCID 200320083-[4-(Pyridin-2-yl) piperazin-1-yl]propane-1,2-diol dihydrochloride収率 53.6%

実験手順

Operation was carried out in a manner similar to the one previously described, using 2-chloropyridine and 1-(2,3-dihydroxypropyl) piperazine. The residue obtained after evaporation to dryness was dissolved in a small amount of concentrated hydrochloric acid and diluted with isopropanol. After resting, 3-[4-(pyridin-2-yl) piperazin-1-yl]propane-1,2-diol dihydrochloride melting at 238°-242° C., was obtained with the 53.6% yield.

後処理

customThe residue obtained
customafter evaporation to dryness
dissolutionwas dissolved in a small amount of concentrated hydrochloric acid
additiondiluted with isopropanol

出典と根拠

ORDレコード: ord-0b3eaf76757b40b1ab887071bd42494a
出典データセット: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04849422

反応ノート

読み込み中…

参加物